Neel Sarovar Bhavesh

Structural Biology
His group uses an interdisciplinary approach encompassing a wide array of biophysical, biochemical and molecular biology techniques for understanding the structure and function of macromolecules with special thrust on molecular mechanism of Protein-RNA interactions. Liquid-state NMR spectroscopy and X-ray crystallography are synergistically used in his group for determination of atomic resolution structures of protein-RNA complexes that provide a wealth of information pertaining to the binding interfaces, recognition mechanisms, and the forces that stabilize these complexes. Current research focuses on RNA binding proteins that involved in post-transcription regulation of mRNA to decipher a possible general code of RNA recognition. He also uses NMR spectroscopy for metabolic profiling of bio-fluids to understand dysregulation during disease condition and help in identification of biomarkers.