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Saha Institute of Nuclear Physics, GOI, DAE, Sector-1, Block-AF, Bidhan nagar, Kolkata-700 064, West Bengal, India
Research area
RNA structure
Dhananjay Bhattacharyya
Retired Professor-H
Retired from Saha Institute of Nuclear Physics, Kolkata. Adjunct Professor Dept. Biophysics, Bioinformatics, University of Calcutta
Description
My main interest is to understand structure-function relationship of biological macromolecules, particularly nucleic acids. In this regard we concentrate on available crystallographic data, carry out molecular dynamics simulation and ab initio quantum chemical calculations to understand structural stabilization of nuceic acid bases and recognition of nucleic acid by other ligands. In order to understand different structural features of nucleic acids, we have developed few softwares, such as NUPARM, BPFIND, PyrHBFind, RNAHelix, etc. Using some of these these tools, we have classified structures of different non-canonical base pairs appearing in RNA crystal structures.
Our latest database on base pairs in RNA is available at http://pdbi.nii.ac.in/~rnabpdb/rnabpdb
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